Author

Sheila Nicholson

BC Cancer Agency

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:software / tool· 2 Assay:whole-genome sequencing· 2 Approach:Bayesian inference· 1 Research Focus:clustering· 1 Research Focus:deconvolution· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

Branden J. LynchiD· 2 shared David D. HuntsmaniD· 2 shared Ding Ma· 2 shared Alexandre Bouchard‐CôtéiD· 1 shared Andrew J. L. RothiD· 1 shared Carlos Vasquez-RiosiD· 1 shared Caroline BariliD· 1 shared Elena ZaikovaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Branden J. LynchORCID

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2 papers

Recent·Most cited

Minimally invasive monitoring of clonal evolution through integrated single cell and ctDNA analysis

Farhia Kabeer, Matteo Lepur, Branden J. Lynch, Emilia Hurtado, Elena Zaikova, Janine Senz, Vinci Au, Caroline Baril, Ding Ma, Sheila Nicholson, Gavin Ha, JESSICA N. MCALPINE, Samuel A. J. R. Aparicio, David D. Huntsman, Alexandre Bouchard‐Côté, , Andrew J. L. Roth

cfClone, a Bayesian model, deconvolves cfDNA whole-genome sequencing using scWGS-derived haplotype-specific clone copy-number profiles to estimate tumour fraction, clonal prevalence, and flag missed clones.

bioRxiv · Aug 19, 2026 · PreprintCancer Biology✦ In-depth digest

Utanos: A general-purpose shallow whole-genome sequencing analysis workflow identifies interpretable copy number signatures

J. Maxwell Douglas, Branden J. Lynch, Jacky Chun Hei Yiu, Sheila Nicholson, Carlos Vasquez-Rios, Ding Ma, David D. Huntsman, Yongjin Park

Utanos provides a modular workflow for analyzing shallow whole-genome sequencing data to detect copy number aberrations and signatures.

bioRxiv · Jul 27, 2026 · PreprintBioinformatics