Minimally invasive monitoring of clonal evolution through integrated single cell and ctDNA analysis
Farhia Kabeer, Matteo Lepur, Branden J. Lynch, Emilia Hurtado, Elena Zaikova, Janine Senz, Vinci Au, Caroline Baril, Ding Ma, Sheila Nicholson, Gavin Ha, JESSICA N. MCALPINE, Samuel A. J. R. Aparicio, David D. Huntsman, Alexandre Bouchard‐Côté, , Andrew J. L. Roth
cfClone, a Bayesian model, deconvolves cfDNA whole-genome sequencing using scWGS-derived haplotype-specific clone copy-number profiles to estimate tumour fraction, clonal prevalence, and flag missed clones.
bioRxiv · Aug 19, 2026 · PreprintCancer Biology✦ In-depth digest