Author

Shichun Lun

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

William R. BishaiiD· 4 shared Eileen P. ScullyiD· 2 shared Joseph P. HoffmanniD· 2 shared Manish Gupta· 2 shared Sabal ChaulagainiD· 2 shared Sabra L. KleiniD· 2 shared Stefanie KrugiD· 2 shared Barbara Stauch SlusheriD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersImmunology

William R. BishaiORCID

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4 papers

Recent·Most cited

Intrinsic T-cell programming and immune spatial organization govern sex-biased tuberculosis immunity

Manish Gupta, Stefanie Krug, Sarita Neupane, Moagi Tube Shaku, Sabal Chaulagain, Shichun Lun, Joseph P. Hoffmann, Eileen P. Scully, Sabra L. Klein, William R. Bishai

This study identifies intrinsic T-cell programming and pulmonary immune spatial organization as sex-dependent mechanisms governing tuberculosis immunity in mice.

bioRxiv · Jul 11, 2026 · PreprintImmunology

Gonadal regulation of sex-specific immunity in tuberculosis: enhanced lymphocyte function in females and dysfunctional myeloid responses in males

Manish Gupta, Nishtha Nayyar, Jessica Shen, Shichun Lun, Sabal Chaulagain, Nikita Mangla, Oscar J Nino-Meza, Stefanie Krug, Geetha Srikrishna, Joseph P. Hoffmann, Eileen P. Scully, Sabra L. Klein, William R. Bishai

This study shows that gonadal sex, not chromosomal sex, influences TB susceptibility in mice, with males showing myeloid dysfunction and females showing enhanced immune responses.

bioRxiv · Jun 12, 2026 · PreprintImmunology

BCG vaccination mitigates tau pathology and restores cognitive function in PS19 mice.

Somnath Shee, Meixiang Huang, Meghraj Singh Baghel, Yuxin Zheng, Shichun Lun, Santosh K. Yadav, Nirbhay Narayan Yadav, Carlos E Ruiz-Gonzalez, Sandeep Tyagi, Eric L. Nuermberger, Sanjay Kumar Jain, Zaver M. Bhujwalla, Barbara Stauch Slusher, Philip C. Wong, William R. Bishai

BCG therapy reduces tau pathology and improves cognitive function in PS19 mice by modulating myeloid cell activity and neuroinflammation.

bioRxiv · May 15, 2026 · PreprintNeuroscience

Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion

Benjamin N. Koleske, Rajagopalan Saranathan, Courtney Schill, Shichun Lun, Catherine Vilchèze, Lahari Das, Manish Kumar Gupta, Yazmin B. Martinez-Martinez, William R. Bishai, William R. Jacobs

This study shows that deleting the ESX-5 secretion system in Mycobacterium tuberculosis reduces ESX-5 substrate secretion, increases ESX-1 substrates, decreases ESX-3 expression, and alters cell morphology and antibiotic susceptibility.

Proceedings of the National Academy of Sciences · Sep 3, 2025Peer-reviewedMicrobiology