Author

Shirong Lai

Fujian Medical UniversityPrimary ORCID profile (0009-0008-7615-0861 · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Shirong LaiiD4 papers · Purdue University West Lafayette

Biology Disciplines

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Bioinformatics· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:metagenomics· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 3 Approach:machine learning (classical)· 2 Approach:benchmark study· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Fenglong YangiD· 5 shared Wenkai LaiiD· 5 shared Meiling WangiD· 3 shared Shanwen SuniD· 2 shared Shaoping HuangiD· 2 shared Da Zhao· 1 shared Furong Tang· 1 shared Fuxin LiniD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersBioinformatics

Fenglong YangORCID

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Author profile →

5 papers

Recent·Most cited

The FERM Guild: A Differentially Correlated Microbial Module Drives Hypertension via Metabolic Flux Perturbations

Wenkai Lai, Yuchen Zhang, Shaoping Huang, Shirong Lai, Fuxin Lin, Ziwei Wang, Shanwen Sun, Fenglong Yang

The paper identifies a microbial module, the FERM guild, associated with hypertension through metabolic flux changes using pFBA and DoubleML.

mSystems · Aug 4, 2026Peer-reviewedBioinformatics

Integrative Multi-Omics Analysis of Gut Microbiota Dysbiosis and Host-Microbiome Interaction Mechanisms in Hypertension

Wenkai Lai, Shaoping Huang, Yu Zhang, Shirong Lai, Shanwen Sun, Furong Tang, Haidan Yan, Fenglong Yang

The paper investigates gut microbiota dysbiosis in hypertension and its interactions with the host immune system using multi-omics data and single-cell analysis.

bioRxiv · Jun 21, 2026 · PreprintMicrobiology

Gut Microbial Metabolic Disorder in Depression: Insights from Computational Modeling and Mediation Analysis

Yuchen Zhang, Wenkai Lai, Meiling Wang, Shirong Lai, Qing Liu, Qi Luo, Zheng Chen, Da Zhao, Ziwei Wang, Fenglong Yang

This study identifies differential gut microbiota species and metabolic fluxes associated with depression using computational modeling and mediation analysis.

BMC Microbiology · Apr 14, 2026Peer-reviewedBioinformatics

Systematic Mining of gut microbiota biomarkers for IBD

Yuchen Zhang, Wenkai Lai, Meiling Wang, Shirong Lai, Qing Liu, Qi Luo, Lijun Dou, Fenglong Yang

The paper identifies microbiota biomarkers and metabolic pathways associated with IBD using metagenomic data from 3044 samples, revealing species and pathway differences between IBD and healthy individuals.

bioRxiv · Oct 10, 2024 · PreprintBioinformatics

Gut microbial metabolic flux disorder in hypertension

Wenkai Lai, Yuchen Zhang, Meiling Wang, Shirong Lai, Qing Liu, Qi Luo, Quan Zou, Fenglong Yang

This study identifies metabolic flux disorders in gut microbiota associated with hypertension by analyzing microbial interactions and metabolite changes.

bioRxiv · Oct 9, 2024 · PreprintBioinformatics