Ziwei Wang

Matrix stiffness shapes immunometabolic states and response to PD-1 blockade in gastric cancer

This study shows that matrix stiffness in gastric cancer affects immunometabolic states and response to PD-1 blockade, with softer matrices improving treatment efficacy.

Persistent Post-Inflammatory Matrix Stiffening Defines a Premalignant Mechanical Niche in Ulcerative Colitis-Associated Neoplasia

This study identifies persistent post-inflammatory matrix stiffening as a premalignant mechanical niche in UC-associated neoplasia, showing its role in epithelial remodeling and potential therapeutic targeting.

Structure-aware protein function prediction at isoform resolution

This study develops a framework for predicting protein function and domain annotation at isoform resolution using structural and sequence data, showing strong performance in benchmark tests and capturing domain changes across isoforms.

Spatiotemporal transcriptome atlas of human embryos after gastrulation

The paper creates a spatiotemporal transcriptome atlas of human embryos after gastrulation, revealing organ-specific regulons and regulatory networks during development.

Wheat MYB transcription factor TaMYB83-7B regulates seed dormancy by influencing the balance between abscisic acid and gibberellin

This study identifies TaMYB83-7B as a wheat transcription factor regulating seed dormancy by modulating the ABA-GA balance, with specific promoter mutations linked to dormancy strength.

Gut Microbial Metabolic Disorder in Depression: Insights from Computational Modeling and Mediation Analysis

This study identifies differential gut microbiota species and metabolic fluxes associated with depression using computational modeling and mediation analysis.

Yeast replicative aging leads to permanent cell cycle arrest in G1 effectuated by the start repressor Whi5

This study shows that yeast replicative aging causes permanent G1 cell cycle arrest mediated by the Whi5 repressor, with increased Whi5 concentration correlating with G1 lengthening and cell death.