Author

Shiye Chen

Adelaide University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Eugene RoscioliiD· 2 shared Hubertus P. A. JersmanniD· 2 shared Susan Elizabeth LesteriD· 2 shared Alejandro ChaveziD· 1 shared Andrew A. SprouliD· 1 shared Andrew F. TeichiD· 1 shared Anton BlencoweiD· 1 shared Arash BadieiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Eugene RoscioliORCID

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Author profile →

4 papers

Recent·Most cited

Autophagy is suppressed in peripheral blood mononuclear cells during chronic obstructive pulmonary disease.

James M Cooper, Shiye Chen, Susan Elizabeth Lester, Julia Kim, Jason Gummow, Thomas Crowhurst, Emily Lawton, Arash Badiei, Phan Nguyen, Paul N Reynolds, Hubertus P. A. Jersmann, Eugene Roscioli

The paper shows that autophagy is suppressed in peripheral blood mononuclear cells of COPD patients, as indicated by reduced autophagic flux and fewer autophagy-related vacuoles.

International Journal of Molecular Sciences · Jun 13, 2026Peer-reviewedMolecular Biology

High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer's disease

Christopher L. Cardona, Lai Wei, Joonwon Kim, Ellen Angeles, Gunjandeep Singh, Shiye Chen, Ronak Patel, Nkechime Ifediora, Peter Canoll, Andrew F. Teich, Gunnar Hargus, Alejandro Chavez, Andrew A. Sproul

This study identifies genetic regulators of microglial inflammation in Alzheimer's disease using CRISPRi screens and scRNA-seq, revealing key genes that modulate inflammatory states and disease-relevant clusters.

Journal of Neuroinflammation · Dec 3, 2025Peer-reviewedNeuroscience

Modifying Azithromycin to Mitigate Arrested Autophagy

Ryan D. Quarrington, Shiye Chen, Sylvia A. Sapula, Shawn W H Liu, Susan Elizabeth Lester, Matthew M Miller, Vesna Munić Kos, Benjamin T. Kopp, Hubertus P. A. Jersmann, Anton Blencowe, Eugene Roscioli

This paper shows azithromycin inhibits autophagy and presents a modified version, AZM-[O], that reduces this effect while retaining antimicrobial and immunomodulatory functions.

bioRxiv · Apr 25, 2024 · PreprintBiochemistry

Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming

Jie Yang, Ruijun Tang, Shiye Chen, Yinan Chen, Liudeng Zhang, Kai Yuan, Rui Huang, Liming Wang

This study shows that ancestral high-sugar diet exposure in Drosophila leads to transgenerational changes in sweet sensitivity and feeding behavior through H3K27me3 reprogramming.

eLife · Sep 12, 2023Peer-reviewedNeuroscience