Biomarker-driven and gene-enhanced viral therapy for malignant peripheral nerve sheath tumor
Meghna Saxena, Love Li, Brady G. Strittmatter, Kyle Brandon Williams, Faruck Lukmanul Hakkim, Shraddha Potti, Alanna Halloran, Elsie Warren, Danielle N Maryanski, Courtney Barnes, Christopher M. Stehn, Madilyn R. Stahl, Chungchi Lee, Alex T. Larsson, Zachary J. Seeman, , Robert Thomas Galvin
This study develops a gene-enhanced HSV therapy for MPNST by exploiting PRC2 loss and tumor-regulated ICP34.5 expression to improve viral efficacy.
bioRxiv · Oct 14, 2026 · PreprintCancer Biology