Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex
Chao Li, Xue-Nan Sun, Jan-Bernd Funcke, Lauri Vanharanta, Nolwenn Joffin, Yan Li, Xavier Prasanna, Megan Paredes, Chanmin Joung, Ruth Gordillo, Csaba Vörös, Waldemar Kulig, Leon Straub, Shuiwei Chen, Joselin Velasco, , Philipp E. Scherer
This study identifies Adig as a regulator of lipid droplet formation by stabilizing the dodecameric seipin complex, leading to increased fat mass and thermogenesis in mice.
bioRxiv · Jul 25, 2024 · PreprintCell Biology