Structures of potent and convergent neutralizing antibodies bound to the SARS-CoV-2 spike unveil a unique epitope responsible for exceptional potency
Shuo Du, Yunlong Cao, Qinyu Zhu, Guopeng Wang, Xiaoxia Du, Runsheng He, Hua Xu, Yinghui Zheng, Bo Wang, Yali Bai, Chenggong Ji, Ayijiang Yisimayi, Qisheng Wang, Ning Gao, X. Sunney Xie, , Junyu Xiao
The paper reports the cryo-EM structure of a potent SARS-CoV-2 NAb, BD-368-2, showing it blocks ACE2 binding and induces structural changes in the spike trimer, distinct from other NAbs.
Cell · Nov 1, 2020Peer-reviewedImmunology