Author

Runsheng He

Peking University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:ATAC-seq· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CUT&Tag· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Xiaoliang Sunney XieiD· 3 shared Fanchong JianiD· 2 shared Honggui WuiD· 2 shared Jiankun ZhangiD· 2 shared Jun ReniD· 2 shared Shuang LiuiD· 2 shared Wenping MaiD· 2 shared Wenyang Dong· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersGenomics

Xiaoliang Sunney XieORCID

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Author profile →

4 papers

Recent·Most cited

Mapping eukaryotic chromatin accessibility and histone modifications with DNA deaminase

Wenyang Dong, Jiankun Zhang, Leyi Dai, Jinxin Phaedo Chen, Honggui Wu, Runsheng He, Yuxuan Pang, Zhi Wang, Fanchong Jian, Jun Ren, Yijun Liu, Yu Tian, Shuang Liu, Xuechen Zhao, Xiaoliang Sunney Xie

The paper introduces two new methods, ChrODIE and ANDIE, for mapping chromatin accessibility and histone modifications without enzymatic cleavage, enabling multi-omics integration.

bioRxiv · Dec 24, 2024 · PreprintGenomics

Human transcription factor combinations mapped by footprinting with deaminase

Runsheng He, Wenyang Dong, Zhi Wang, Chen Xie, Long Gao, Wenping Ma, Ke Shen, Dubai Li, Yuxuan Pang, Fanchong Jian, Jiankun Zhang, Yuan Yuan, Xinyao Wang, Zhen Zhang, Yinghui Zheng, , Xiaoliang Sunney Xie

The paper introduces a method to map transcription factor binding sites genome-wide with single-base resolution and applies it to study cell-type-specific TF cooperativity in human tissues.

Proceedings of the National Academy of Sciences · Dec 17, 2024Peer-reviewedGenomics

Structures of potent and convergent neutralizing antibodies bound to the SARS-CoV-2 spike unveil a unique epitope responsible for exceptional potency

Shuo Du, Yunlong Cao, Qinyu Zhu, Guopeng Wang, Xiaoxia Du, Runsheng He, Hua Xu, Yinghui Zheng, Bo Wang, Yali Bai, Chenggong Ji, Ayijiang Yisimayi, Qisheng Wang, Ning Gao, X. Sunney Xie, , Junyu Xiao

The paper reports the cryo-EM structure of a potent SARS-CoV-2 NAb, BD-368-2, showing it blocks ACE2 binding and induces structural changes in the spike trimer, distinct from other NAbs.

Cell · Nov 1, 2020Peer-reviewedImmunology

Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus

Feng Tian, Fan Zhou, Xiang Li, Wenping Ma, Honggui Wu, Ming Yang, Alec R. Chapman, David F. Lee, Longzhi Tan, Dong Xing, Guangjun Yin, Ayjan Semayel, Jing Wang, Jia Wang, Wenjie Sun, , Xiaoliang Sunney Xie

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.

bioRxiv · Apr 12, 2020 · PreprintGenomics