Acquired epithelial Wnt7b secretion establishes autocrine WNT dependency in BRAF mutant colorectal cancer
Simon Lampart, Tasnim Khadam-Al-Jame, Peter Leary, Ab Meijs, Clelia Pistoni, Tosca Dalessi, Randall J. Platt, Ralph Fritsch, Hassan Fazilaty, Tomáš Valenta
This study identifies Wnt7b as a critical autocrine WNT ligand required for survival of BRAF-mutant colorectal cancer organoids and shows its association with poor patient survival in human tumors.
bioRxiv · Sep 25, 2026 · PreprintMolecular Biology