Simon R Cox

Interplay between polygenic effects and polypharmacy on dementia: An investigation in an elderly Scottish cohort.

The paper investigates the interaction between polygenic risk scores for Alzheimer's dementia and polypharmacy in predicting future dementia risk in an elderly Scottish cohort.

Imputed DNA methylation outperforms measured loci associations with smoking and chronological age

The paper shows that imputing DNA methylation loci from epigenome-wide data provides stronger associations with smoking and age than directly measured CpGs.

Blood-based DNA methylation study of alcohol consumption

This paper develops an epigenetic score to objectively measure alcohol consumption using blood-based DNA methylation and validates it across multiple cohorts, finding associations with brain health metrics.

Integration of DNA methylation datasets for individual prediction

The paper evaluates normalization methods for DNA methylation data to improve BMI prediction across cohorts when projecting new data onto a reference panel.

General factors of white matter microstructure from DTI and NODDI in the developing brain

The paper uses DTI and NODDI metrics from 16 white matter tracts in preterm and term infants to identify general factors that capture shared variance and predict preterm birth outcomes.

Epigenetic scores for the circulating proteome as tools for disease prediction

The paper develops epigenetic scores (EpiScores) for plasma proteins to predict disease risk, finding 137 associations with incident morbidities independent of known factors.

Characterizing the human methylome across the life course: findings from eight UK-based studies

This study maps DNA methylation changes across the human life course using data from 7,037 individuals, showing increased variability and age-related mean changes at specific CpG sites.

Epigenetic predictors of lifestyle traits applied to the blood and brain

The paper applies blood-derived epigenetic predictors of lifestyle traits to brain samples, finding variable correlations across brain regions and a strong link between smoking and the dorsolateral prefrontal cortex.

Hierarchical complexity of the macro-scale neonatal brain

This study examines hierarchical complexity in neonatal and adult brain networks, finding greater complexity in term-born neonates compared to preterms, linked to connectivity patterns in intermediate tiers.

Polygenic architecture of human neuroanatomical diversity

This study examines the genomic architecture of neuroanatomical diversity using SNP data and MRI, finding polygenic influences and environmental factors affecting brain asymmetry.

Associations between vascular risk factors and brain MRI indices in UK Biobank

This study examines associations between vascular risk factors and brain MRI indices in UK Biobank, finding that higher vascular risk is linked to poorer brain health across macro- and microstructural measures.

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

Across 5,216 UK Biobank adults, males had larger brain volumes and surface areas, females thicker cortices and stronger default-mode connectivity; male variance was generally greater.

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

The paper analyzes white matter microstructure in UK Biobank data to show age-related changes in diffusion measures and connectivity patterns.