Author

Simon Umbach

Goethe University Frankfurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

ALEXANDER R. GOTTSCHALKiD· 1 shared Amelie C. F. BergsiD· 1 shared Arne MölleriD· 1 shared Barbara Jánosi· 1 shared Daniel HilgeriD· 1 shared Dennis RentschiD· 1 shared Dovile JanulieneiD· 1 shared Frank BernhardiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperNeuroscience

ALEXANDER R. GOTTSCHALKORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

RIM and RIM-binding protein localize synaptic Cav2 channels to differentially regulate transmission in neuronal circuits

Barbara Jánosi, Jana Fiona Liewald, Marius Seidenthal, Szi-chieh Yu, Simon Umbach, Jasmina Redzovic, Dennis Rentsch, Ivan C. Alcantara, Amelie C. F. Bergs, Martin Schneider, Jiajie Shao, ALEXANDER R. GOTTSCHALK

The paper investigates how RIM and RIM-binding proteins regulate synaptic transmission by localizing Cav2 channels in C. elegans neuromuscular junctions, showing differential effects on cholinergic and GABAergic transmission.

Journal of Neuroscience · Jul 1, 2024Peer-reviewedNeuroscience

Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid nanodisc environment

Zoe Köck, Kilian Schnelle, Margherita Persechino, Simon Umbach, Hannes Schihada, Dovile Januliene, Kristian Parey, Steffen Pockes, Peter Kolb, Volker Dötsch, Arne Möller, Daniel Hilger, Frank Bernhard

The paper presents the cryo-EM structure of the human histamine H2 receptor complexed with Gs protein in lipid nanodiscs, revealing insights into ligand binding and G protein coupling mechanisms.

bioRxiv · Jul 27, 2023 · PreprintMolecular Biology