Volker Dötsch

This study develops peptide-based tracers for SPSB2 E3 ligase by conjugating cell-penetrating peptides to degrons, enabling efficient cellular delivery and target engagement assessment.

The paper determines the cryo-EM structure of a full-length human β1-adrenergic receptor in complex with Gs, revealing structural insights into ICL3's role in G protein activation.

This paper presents the NMR structure and functional analysis of the Uba7 UFD domain and its interaction with UbcH8, revealing structural flexibility and key residues critical for E2 recognition in the ISGylation pathway.

The paper identifies Ypl225w as a chaperone that facilitates GTP-driven co-translational folding of eEF1A by interacting with the ribosome and NAC.

The paper identifies branch- and length-specific ubiquitin chain interactors in humans and yeast, revealing how different Ub architectures are decoded by proteins.

The paper presents the cryo-EM structure of the human histamine H2 receptor complexed with Gs protein in lipid nanodiscs, revealing insights into ligand binding and G protein coupling mechanisms.

The paper shows that TAp63 uses a slow third phosphorylation step to set a threshold for apoptosis induction in response to DNA damage.