Dicer-to-Argonaute switch controls biogenesis of oncogenic miRNA
Laura M. Winchester, Linda van Bijsterveldt, Andrew Dhawan, Simon Wigfield, Charalampos P. Triantafyllidis, Syed Aleem Haider, Alan McIntyre, Timothy C. Humphrey, Adrian Llewellyn Harris, Francesca Meteora Buffa
The paper identifies a switch from DICER-dependent to Argonaute-mediated miRNA biogenesis in cancer, showing that non-canonical processing of oncogenic miRNAs promotes cancer progression.
bioRxiv · Aug 30, 2021 · PreprintGenomics