Gut microbiota-derived indole-3-propionic acid preserves dorsal hippocampal catecholamines to prevent post-stroke cognitive impairment
Yisi Liu, Huaying Zhang, Fangbo Xia, Xuxuan Gao, Fan Wu, Xin Zhao, Mengxi Li, Yanni Zheng, Siqi Yan, Kaiyu Xu, Muxuan Chen, Yueran Ren, Weike Hu, Zhuang Li, Jia Yin, , Dongxin Zhang
This study identifies indole-3-propionic acid (IPA) as a gut microbiota-derived metabolite that prevents post-stroke cognitive impairment by preserving catecholamines in the dorsal hippocampus.
mSystems · Oct 7, 2026Peer-reviewedNeuroscience