Degradation rather than disassembly of necrotic debris is essential to enhance recovery after acute liver injury
Sara Schuermans, Jusal P. Quanico, Caine Kestens, Sofie Vandendriessche, Emily Slowikowski, Maria Laura Crijns, Noëmie Pörtner, Nele Berghmans, Geert Baggerman, Matheus Silvério Mattos, Paul Proost, Pedro Elias Marques
This study shows that enzymatic degradation of necrotic debris improves recovery after liver injury, while disassembly strategies like peptide treatment or plasmin activation are less effective or harmful.
Cellular and Molecular Life Sciences · Apr 29, 2025Peer-reviewedImmunology