GDF15 modifies NAD+ salvage pathway and dampens immune response in mitochondrial disease
Anastasiia Marmyleva, Nahid A Khan, Liliya Euro, Sonja Jansson, Anu Suomalainen
This study shows GDF15 enhances NAD+ salvage and reduces immune response in mitochondrial disease by upregulating NMRK2 and modulating redox homeostasis.
bioRxiv · Nov 2, 2026 · PreprintCell Biology