ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance
Songnan Wang, Yingjie Guo, Weidong An, J. Michelle Lee, Yu Li, Valentino Sudaryo, Jacqueline A. Carozza, Gabriel Grenot, Gemini M. Skariah, Saranya Chidambaranathan Reghupaty, Sonny Young, Xiaochen Bai, Katrin J. Svensson, Lingyin Li
This study shows that the ENPP1 K173Q variant reduces cGAMP hydrolysis, leading to increased extracellular cGAMP and insulin resistance in brown adipose tissue.
Cell Reports · Sep 15, 2026Peer-reviewedImmunology