Cell BiologybioRxiv
TCF7L2 is a master regulator of insulin production and processing
Yuedan Zhou, Soo-Young Park, Jing Su…·Ola Hansson
This study identifies TCF7L2-target genes and their regulatory network in insulin secretion, showing TCF7L2 regulates proinsulin synthesis, processing, and clearance in rodents and human islets.