Soohyun Lee

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes

The paper identifies enhancer-AAV tools for specific neuronal subtypes and validates them across species.

Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles

This study shows that loss of Ezh2 in the medial ganglionic eminence (MGE) leads to changes in interneuron fate, morphology, and gene expression.

A novel method for an unbiased estimate of cross-ancestry genetic correlation using individual-level data

This paper introduces a method to estimate cross-ancestry genetic correlation using individual-level data, finding significant genetic heterogeneity in obesity between African and European ancestry groups.

Significance tests for R2 of out-of-sample prediction using polygenic scores

The paper develops statistical methods to estimate variance and covariance of R2 values for polygenic scores, enabling significance testing of predictive ability differences across samples and SNP types.

A novel hyper-parameter can increase the prediction accuracy in a single-step genetic evaluation

This paper introduces a new hyper-parameter, the scale factor, to improve the prediction accuracy of the HBLUP method in genetic evaluation using simulated and real cattle data.

Pseudomonas syringae evades phagocytosis in animal cells through type III effector-mediated inhibition of the LIM kinase-cofilin system

This study shows that Pseudomonas syringae evades phagocytosis in mice by inhibiting actin rearrangement through a type III effector that targets LIM kinase.