Heterochromatin-based silencing of a foreign tandem repeat in Drosophila melanogaster shows unusual biochemistry and temperature sensitivity
Tingting Gu, Elena Gracheva, Michael Lee, Wilson Leung, Sophia Bieser, Alixandria Nielsen, Adam T. Smiley, Nhi N T Vuong, Matthias Walther, Gunter Reuter, Sarah C. R. Elgin, Andrew M. Arsham
The paper shows that a foreign tandem repeat can induce heterochromatin formation in Drosophila, with temperature-dependent silencing and distinct biochemistry compared to canonical PEV.
Genetics · Dec 24, 2025Peer-reviewedGenetics