Evolutionary BiologybioRxivPreprint
Relaxed constraint and thermal desensitization of the cold-sensing ion channel TRPM8 in mammoths
Sravanthi Chigurapati, Mike Sulak, Webb Miller, Vincent J. Lynch
This study identifies mammoth-specific TRPM8 mutations that confer thermal desensitization while preserving sensitivity to chemical coolants.
DOI 10.1101/397356