Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties
Jae Hun Shin, Jooyoung Park, Jaechul Lim, Jaekwang Jeong, Ravi K. Dinesh, Stephen E. Maher, Jeonghyun Kim, So Yeon Park, Jun Young Hong, John J. Wysolmerski, Jungmin Choi, Alfred L.M. Bothwell
This study shows DKK2 is required for colon cancer metastasis by generating cancer cells with Paneth cell properties through HNF4A regulation.
bioRxiv · Apr 12, 2024Cancer Biology