NAD+ Replenishment Reduces Cardiomyocyte Senescence and Improves Diastolic Function in the Aged Male Heart
Qingxia Huang, Yongjie Wang, Karina Farias, Xinliu Zeng, Qiuying Chen, Huiyong Cheng, Vijaya B Baki, Steve Gross, Jacob Geri, Anthony A. Sauve, Yue Yang
This study shows that NAD+ replenishment with NR or NRH reduces cardiomyocyte senescence and improves diastolic function in aged male mice but not females.
Cardiovascular Research · Oct 29, 2026Peer-reviewedPharmacology & Toxicology