CAR T cell targeting of inflammatory myeloid progenitors in the bone marrow remodels border-associated macrophages and reverses cognitive aging
Alexander S. Harris, James A. Rouse, 郭广冉, Inés Fernández-Maestre, Sujay Pal, Brian Oh, Shuxuan Li, Wen Yi See, Arianna Anderson, Joseph Gewolb, Matthew Soethout, Jill Habel, Rad Utama, Christopher R. Vakoc, Corina Amor
This study shows that targeting inflammatory myeloid progenitors in the bone marrow with CAR T cells reduces neuroinflammation and cognitive decline in aging and Alzheimer's models.
bioRxiv · Sep 28, 2026 · PreprintCell Biology