Brain-resident myeloid cells promote rapid leukocyte adhesion in leptomeningeal vessels after anti-Aβ immunotherapy
Moustafa Algamal, Shinya Yokomizo, Wadzanai Ndambakuwa, Sarena Abdallah, Maria Virtudes Sanchez-Mico, Rebecca L. Gillani, Patrick da Silva, Aryan Rajput, Lakshita Palanivelu, Yuna Lee, Katy R. Walsh, Sunny Kumar, Kıvılcım Kılıç, Joseph B. El Khoury, Saef Izzy, , Brian J. Bacskai
This study shows anti-Aβ immunotherapy triggers rapid immune-vascular interactions in the leptomeningeal interface, leading to peripheral immune cell adhesion and potentially contributing to ARIA.
bioRxiv · Sep 11, 2026 · PreprintNeuroscience