Abnormal shear stress induces ferroptosis in endothelial cells via KLF6 downregulation
Jingang Cui, Zhiyu Fan, Suoqi Ding, Jiazhen Zhang, He Shen, Syeda Armana Zaidi, Yongsheng Ding
This study shows abnormal shear stress induces ferroptosis in endothelial cells by downregulating KLF6, leading to reduced SLC7A11 and CoQ10 levels and increased lipid peroxidation.
bioRxiv · Sep 10, 2025 · PreprintCell Biology