Harmine Selectively Drives Human Beta Cell Differentiation and Function Via Protein Kinase A Pathways
Peng Wang, Kunal Kumar, Luca Lambertini, Hongtao Liu, Olivia Wood, Shuxuan Chen, Aidan Pillard, Donald K. Scott, João A. Paulo, Steven P. Gygi, Susmita Khamrui, Stefan Mueller, Adolfo Garcı́a-Ocaña, Esra Karaköse, Michael B. Lazarus, , Andrew F. Stewart
This paper shows harmine, a DYRK1A inhibitor, selectively promotes human beta cell differentiation and function via PKA activation, distinct from other DYRK1A inhibitors.
bioRxiv · Dec 8, 2025 · PreprintCell Biology