Luca Lambertini

The paper identifies AP-1 family transcription factors as critical regulators of beta cell maturation by analyzing epigenomic and transcriptomic profiles of human insulinomas.

This paper shows harmine, a DYRK1A inhibitor, selectively promotes human beta cell differentiation and function via PKA activation, distinct from other DYRK1A inhibitors.

This study shows that nutrient excess remodels pancreatic islet innervation through Schwann cells, impairing glycemic control, and demonstrates that neuromodulation can improve outcomes.

This study uses single-cell RNA sequencing to identify cycling alpha cells as key beta cell progenitors in response to DYRK1A inhibitor treatment in human pancreatic islets.

This study identifies harmine, 2-2c, and 5-IT as DYRK1A inhibitors that enhance both beta cell proliferation and differentiation, while others fail to induce differentiation.