Quinazolinone and Phthalazinone Inhibitors of the HDAC6/Ubiquitin Protein-Protein Interaction
Sydney Gordon, Jordi C. J. Hintzen, Sebastian Dilones, Brockton Keen, Callie E. W. Crawford, George M. Burslem
The paper identifies and optimizes quinazolinone and phthalazinone inhibitors targeting the HDAC6 ZnF-UBD/ubiquitin interaction, using computational and experimental methods to improve their physicochemical properties and predict binding affinity.
ChemBioChem · Jun 24, 2026Peer-reviewedBiochemistry