Author

Sylvia Menzel

RWTH Aachen University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:imputation· 1 Organism:mouse· 1

Frequent Co-Authors

Rafael KramanniD· 3 shared Christoph KuppeiD· 2 shared David SchumacheriD· 2 shared Ivan G. CostaiD· 2 shared Konrad HoeftiD· 2 shared Mingbo ChengiD· 2 shared Peter BooriD· 2 shared Rebekka K. SchneideriD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersSystems Biology

Rafael KramannORCID

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3 papers

Recent·Most cited

Cyclic uremia without kidney injury drives cardiovascular disease with rapid onset of immunosenescence and heart failure

Gideon J L Schaefer, Patrick Droste, Carla Sophie Schikarski, Xinhui Li, Marius Kohl, Niklas Lutterbach, Henriëtte de Loor, Lars Koch, Sylvia Menzel, Ling Zhang, Qingqing Long, Kristian Vogt, Anne-Sophie Andries, Anne Babler, David Schumacher, , Konrad Hoeft

This study establishes a mouse model of cyclic uremia without kidney injury, showing it drives cardiovascular disease and immunosenescence independently of traditional risk factors.

bioRxiv · Sep 30, 2026 · PreprintSystems Biology

Spatial multi-omic map of human myocardial infarction

Christoph Kuppe, Ricardo O. Ramirez Flores, Zhijian Li, Sikander Hayat, Rebecca T. Levinson, Xian Liao, Monica Toft Hannani, Jovan Tanevski, Florian Wünnemann, James Shiniti Nagai, Maurice Halder, David Schumacher, Sylvia Menzel, Gideon Schäfer, Konrad Hoeft, , Rafael Kramann

This study generates a high-resolution spatial multi-omic map of human myocardial infarction by integrating single-cell gene expression, chromatin accessibility, and spatial transcriptomic data to reveal cellular zones of injury, repair, and remodeling.

Nature · Aug 10, 2022Peer-reviewedSystems Biology

Chromatin-accessibility estimation of single-cell ATAC data with scOpen

Zhijian Li, Christoph Kuppe, Susanne Ziegler, Mingbo Cheng, Nazanin Kabgani, Sylvia Menzel, Martin Zenke, Rafael Kramann, Ivan G. Costa

scOpen improves downstream analysis of sparse scATAC-seq data by imputing open chromatin regions, revealing regulatory changes in kidney fibrosis.

bioRxiv · May 10, 2021 · PreprintBioinformatics