Molecular Dynamics Analysis of Mg2+-dependent Cleavage of a Pistol Ribozyme Reveals a Fail-safe Secondary Ion for Catalysis
N. N. Joseph, R. N. Roy, T. A. Steitz
The paper uses molecular dynamics simulations to analyze the role of magnesium ions in pistol ribozyme cleavage, revealing flexible and interchangeable roles of two ions in catalysis.
bioRxiv · Aug 19, 2019Biophysics