Activation of the Anaphase Promoting Complex reverses multiple drug resistant cancer
T. Aranson, V. MacDonald-Dickinson, G. F. Davies, C. Gaunt, L. Lubanova, B. Trost, M. Waldner, P. Baldwin, D. Borrowood, H. Marwood, Z. E. Gillespie, F. Vizeacoumar, F. Vizeacoumar, C. H. Eskiw, A. Kusalik, T. A. A. Harkness
This study shows that activating the Anaphase Promoting Complex (APC) in dogs with multiple drug resistant lymphoma reduces MDR biomarkers and restores chemosensitivity, suggesting APC as a therapeutic target.
bioRxiv · May 26, 2020 · PreprintCancer Biology