Pseudo-mutant p53 as a targetable phenotype of DNMT3A-mutated pre-leukemia
A. Tuval, Y. Brilon, H. Ezogy, Y. Moskovitz, T. Biezuner, D. Leshkowitz, T. M. Salame, M. D. Minden, P. Tal, V. Rotter, M. Oren, N. Kaushansky, L. I. Shlush
The paper identifies a pseudomutant p53 conformation in DNMT3A-mutated pre-leukemic HSPCs and shows that shifting to the wild-type conformation can eliminate these cells.
bioRxiv · May 30, 2021 · PreprintCancer Biology