Author

N. Kaushansky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Solomon· 2 shared L. I. Shlush· 2 shared L. Shlush· 2 shared M. Minden· 2 shared M. Scheller· 2 shared N. Chapal-Ilani· 2 shared Y. Moskovitz· 2 shared A. Bercovich· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

A. Solomon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

J.-S. Kim, S. Trzebanski, S.-H. Shin, N. C. Ilani, N. Kaushansky, M. Scheller, A. Solomon, Z. Liu, O. Aust, S. Boura-Halfon, L. Amann, M. Prinz, F. Ginhoux, R. Avraham, C. Mueller-Tidow, , S. Jung

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

bioRxiv · Nov 16, 2023Immunology

Rock inhibitors target SRSF2 leukemia by disrupting cell mitosis and nuclear morphology

M. Su, T. Fleisher, I. Grosheva, M. B. Horev, M. Olszewska, B. Haim, A. Plotnikov, S. Carvalho, Y. Moskovitz, M. Minden, N. Chapal-Ilani, E. P. Papapetrou, N. Dezorella, T. Cheng, N. Kaushansky, , L. I. Shlush

This study identifies ROCK inhibitors as effective targeting agents for SRSF2 mutant leukemia by disrupting mitosis and nuclear morphology in vitro and in xenograft models.

bioRxiv · Feb 15, 2022 · PreprintCancer Biology

Inflammatory signals from fatty bone marrow supports the early stages of DNMT3a driven clonal hematopoiesis

N. Zioni, A. Bercovich, N. Chapal-Ilani, A. Solomon, E. Petrovich, M. .Sacma, H. Geiger, M. Scheller, C. Müller-Tidow, D. Lipka, E. Shlush, M. Minden, N. Kaushansky, L. Shlush

This study shows that fatty bone marrow (FBM) promotes DNMT3A-driven clonal hematopoiesis by enhancing inflammatory signals like IL-6, which can be inhibited by blocking the IL-6 receptor.

bioRxiv · Jan 13, 2022Cancer Biology

Pseudo-mutant p53 as a targetable phenotype of DNMT3A-mutated pre-leukemia

A. Tuval, Y. Brilon, H. Ezogy, Y. Moskovitz, T. Biezuner, D. Leshkowitz, T. M. Salame, M. D. Minden, P. Tal, V. Rotter, M. Oren, N. Kaushansky, L. I. Shlush

The paper identifies a pseudomutant p53 conformation in DNMT3A-mutated pre-leukemic HSPCs and shows that shifting to the wild-type conformation can eliminate these cells.

bioRxiv · May 30, 2021 · PreprintCancer Biology