Author

T. Defraeye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 2 Approach:mechanistic / dynamical model· 2 Approach:statistical model· 1

Frequent Co-Authors

F. Bahrami· 3 shared R. M. Rossi· 3 shared A. Terrier· 1 shared L. Ding· 1 shared R. I. Malini· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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3 shared papersPharmacology & Toxicology

F. Bahrami

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3 papers

Recent·Most cited

Predicting transdermal fentanyl delivery using physics-based simulations for tailored therapy

F. Bahrami, R. M. Rossi, T. Defraeye

This paper develops a physics-based digital twin to predict transdermal fentanyl delivery and tailor therapy based on patient age, showing increased pain relief and safety in older patients.

bioRxiv · Jan 21, 2021 · PreprintPharmacology & Toxicology

Inverse mechanistic modeling of transdermal drug delivery for fast identification of optimal model parameters

T. Defraeye, F. Bahrami, R. M. Rossi

This paper uses inverse mechanistic modeling to rapidly determine optimal parameters for transdermal drug delivery, improving model accuracy with fewer simulations.

bioRxiv · Dec 11, 2020Pharmacology & Toxicology

Predicting transdermal fentanyl delivery using mechanistic simulations for tailored therapy

T. Defraeye, F. Bahrami, L. Ding, R. I. Malini, A. Terrier, R. M. Rossi

This study uses mechanistic simulations to predict transdermal fentanyl delivery, showing significant variability in uptake by age and anatomical location, and demonstrating the potential of micron-sized reservoirs to enhance drug flux.

bioRxiv · Jun 16, 2020Bioengineering