L. Ding

Lydicamycins Induce Morphological Differentiation in Actinobacterial Interactions

This study identifies lydicamycins as inducers of morphological differentiation in actinobacterial interactions using co-cultivation and multi-omics approaches.

LINC01432 binds to CELF2 in newly diagnosed multiple myeloma promoting short progression-free survival to standard therapy

This study identifies LINC01432 as a lncRNA that binds to CELF2 and inhibits apoptosis in multiple myeloma, contributing to short progression-free survival to standard therapy.

Alligamycin A, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

This paper identifies alligamycin A, a novel antifungal compound from Streptomyces iranensis, and demonstrates its potent antifungal activity against clinically relevant fungi.

Defective Homologous Recombination and Genomic Instability Predict Increased Responsiveness to Carbon Ion Radiotherapy in Pancreatic Cancer

This study identifies PDAC cell lines defective in homologous recombination or with high genomic instability as more responsive to carbon ion radiotherapy, suggesting potential for targeted therapy.

Maramycin, a cytotoxic isoquinolinequinone terpenoid produced through heterologous expression of a bifunctional indole prenyltransferase /tryptophan indole-lyase in S. albidoflavus

The paper reports the discovery of maramycin, a novel isoquinolinequinone alkaloid produced through heterologous expression of a bifunctional enzyme in Streptomyces albidoflavus, showing moderate cytotoxicity against prostate cancer cells.

PRMT5 deficiency disturbs Nur77 methylation to inhibit endometrial stromal cell differentiation in recurrent implantation failure

This study shows PRMT5 deficiency disrupts Nur77 methylation, impairing endometrial stromal cell differentiation and contributing to recurrent implantation failure.

Incorporation of the HIV-1 envelope glycoprotein into viral particles is regulated by the tubular recycling endosome in a cell type-specific manner

Activation of glucocorticoid receptor signaling inhibits KSHV-induced inflammation and tumorigenesis

This study shows that dexamethasone inhibits KSHV-induced inflammation and tumorigenesis by activating GR signaling, which suppresses IL-1 and induces IL-1Ra.

Biosynthesis of the azoxy compound azodyrecin from Streptomyces mirabilis P8-A2

This study identifies and characterizes the biosynthetic pathway for azodyrecin, an azoxy compound produced by Streptomyces mirabilis P8-A2, revealing key enzymes and gene cluster distribution across Streptomyces species.

A novel approach to increase glial cell populations in brain microphysiological systems

This paper introduces a glial-enriched medium to increase astrocyte and oligodendrocyte populations in brain microphysiological systems without compromising neuronal differentiation.

Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors.

This study identifies that clonally diverse CXCR5+ B cells enhance IFNγ pathway activity and CD8 T cell responses, leading to durable ICI therapy outcomes in melanoma.

Targeting CD301+ macrophage inhibits endometrial fibrosis and improves pregnancy outcome

This study identifies CD301+ macrophages as drivers of endometrial fibrosis and infertility, showing their inhibition improves pregnancy outcomes in mice.

SeMOE allows for quantitative glycan perception and exhibits anti-cancer potentiality

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

Tryptophan-based motifs in the LLP3 Region of the HIV-1 envelope glycoprotein cytoplasmic tail direct trafficking to the endosomal recycling compartment and mediate particle incorporation

This paper identifies two tryptophan-based motifs in the HIV-1 Env CT that mediate ERC localization and Env incorporation into viral particles.

Mitochondrial GTP Metabolism Regulates Reproductive Aging

This study shows that mitochondrial GTP metabolism regulates reproductive aging in C. elegans by controlling mitochondrial dynamics and homeostasis.

Temporal colonization of the gut microbiome in neonatal Bos taurus at single nucleotide resolution

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

Early microbial intervention reduces diarrhea while improves later milk production in newborn calves

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

KIF16B mediates anterograde transport and modulates lysosomal degradation of the HIV-1 envelope glycoprotein

This study identifies KIF16B as a host motor protein that facilitates HIV-1 Env trafficking to the plasma membrane, prevents lysosomal degradation, and enhances viral particle incorporation and infectivity.

Streptomyces alleviate abiotic stress in plant by producing pteridic acids

This study identifies pteridic acids produced by Streptomyces that alleviate drought and salinity stress in Arabidopsis by promoting root growth and inducing stress response genes.

A novel method revealing animal evolutionary relationships based on milk Mid-infrared

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance

This study shows that scavenging reactive dicarbonyls with PPM reduces atherosclerosis and insulin resistance in Ldlr-/- mice by improving HDL function and reducing inflammation.

Evaluation of antibody kinetics and durability in health subjects vaccinated with inactivated COVID-19 vaccine (CoronaVac): A cross-sectional and cohort study in Zhejiang, China

This study evaluates antibody kinetics and durability after CoronaVac vaccination in health subjects, finding waning antibody levels over time and improved responses with a booster dose.

Insulin signaling and extended longevity in ants

The paper investigates how insulin signaling and anti-insulin mechanisms in ants link reproduction to extended longevity through gene expression analysis in different castes.

The spatial landscape of Cancer Hallmarks reveals patterns of tumor ecology

The paper uses spatial transcriptomics to analyze Cancer Hallmarks in 63 tumors, revealing spatial patterns of hallmark activity and interdependencies between cancer and tumor microenvironment.

Arf GTPase activates the WAVE Regulatory Complex through a novel binding site

This study identifies a novel Arf1 binding site on WRC that drives activation through a mechanism distinct from Rac1.

Sequential functional differentiation of luminal epithelial cells regulated by maternal and embryonic signaling in the mouse endometrium

The paper identifies maternal and embryonic signaling-driven differentiation of luminal epithelial cells in the mouse endometrium and shows conservation in humans.

Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC

This study shows that pancreas resident macrophages (TRMs) have distinct roles in pancreatitis and pancreatic cancer, promoting fibrosis in inflammation but driving cancer progression.

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

Macrophage proliferation machinery leads to PDAC progression, but susceptibility to innate immunotherapy.

This study shows that TAM proliferation in PDAC is driven by CSF1 from fibroblasts, leading to immunosuppression and tumor progression, but also increasing sensitivity to CD40 agonist therapy.

PDXNet Portal: Patient-Derived Xenograft model, data, workflow, and tool discovery

The paper introduces the PDXNet Portal, a centralized resource for PDX models and data, offering analysis workflows and facilitating cancer research collaboration.