CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor
M. Clement, L. Knezevic, T. Dockree, J. E. McLaren, K. Ladell, K. Miners, S. Llewellyn-Lacey, O. Francis, A. K. Sewell, J. S. Bridgeman, D. A. Price, H. A. van den Berg, L. Wooldridge
The paper shows that CD8 coreceptor interactions can alter the agonist hierarchy of peptide ligands recognized by TCRs, affecting antigen sensitivity without changing TCR structure.
bioRxiv · Sep 23, 2020Immunology