K. Ladell

Highly Multiplexed Proteomic Analysis of HCMV-Infected Dendritic Cells Reveals Global Manipulation of Adaptive Immunity and Host Restriction of Viral Replication

The paper uses proteomic analysis to study HCMV-infected dendritic cells, revealing how the virus manipulates adaptive immunity and restricts replication.

Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes

The paper investigates how inhibitory KIRs modify HLA class II protective associations in Type 1 Diabetes, finding that iKIRs reduce HLA class II-mediated protection.

Splicing-aware resolution of scRNA-Seq data

The paper introduces SANSARA, a method for splicing-aware scRNA-Seq analysis, revealing splicing heterogeneity in T cell subsets and interactions between transcription factors.

Repertoire-based mapping and time-tracking of helper T cell subsets in scRNA-Seq

This paper introduces TCR-Track, a method to map and track helper T cell subsets in scRNA-Seq data, revealing their clonal relationships and functional programs over time.

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways

This paper identifies how HCMV targets ADAM17 to modulate surface proteins and immune pathways, revealing a novel viral immunomodulation strategy.

Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1

The paper identifies IL-10-producing CD4+ T cells that develop via T-bet dependence and Arg1 coexpression, promoting cytomegalovirus persistence.

ADNKA overcomes SARS-CoV2-mediated NK cell inhibition through non-spike antibodies

This study identifies ADNKA as a mechanism by which SARS-CoV-2-infected cells evade NK cell inhibition, showing that non-spike antibodies drive sustained NK activation and cytokine production.

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor

The paper shows that CD8 coreceptor interactions can alter the agonist hierarchy of peptide ligands recognized by TCRs, affecting antigen sensitivity without changing TCR structure.

CD4+ T follicular helper (Tfh) cells in human tonsil and blood are clonally convergent, but divergent from non-Tfh CD4+ cells

The paper examines clonal relationships between Tfh cells in blood and tonsil, finding clonal convergence between peripheral and tonsillar Tfh cells but divergence from non-Tfh CD4+ cells.