The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis
I. M. Dambuza, T. Drake, A. Chapuis, L. Taylor-Smith, N. LeGrave, T. Rasmussen, M. C. Fisher, T. Bicanic, T. S. Harrison, M. Jaspars, R. C. May, G. D. Brown, R. Yuecel, D. M. MacCallum, E. R. Ballou
This paper establishes an in vitro system to induce Titan cells in Cryptococcus neoformans, identifies bacterial peptidoglycan as an inducer, and shows that Titanisation is regulated and conserved across species.
bioRxiv · Sep 19, 2017Microbiology