Author

I. M. Dambuza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Microbiology· 5

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:fungi (other)· 2

Frequent Co-Authors

E. R. Ballou· 3 shared A. Chapuis· 2 shared D. M. MacCallum· 2 shared G. D. Brown· 2 shared R. C. May· 2 shared R. Yuecel· 2 shared X. Zhou· 2 shared A. Balci· 1 shared

Activity by Year

2017-2023 · peak 2/yr

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10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

E. R. Ballou

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5 papers

Recent·Most cited

Human Plasma-Like Medium (HPLM) induces Cryptococcus neoformans in vivo cell morphologies

L. Mukaremera, I. M. Dambuza, R. Yuecel, E. Galue Mozo, O. Ross

This study shows that human plasma-like medium induces C. neoformans to form in vivo-like cell morphologies in vitro, including mixed sizes, increased capsule, and higher chitin and DNA content.

bioRxiv · Aug 29, 2023 · PreprintMicrobiology

Host-derived Reactive Nitrogen Species mediate the Cryptococcus neoformans yeast-to-titan switch via fungal-derived superoxide

X. Zhou, G. E. Desanti, R. C. May, I. M. Dambuza, E. R. Ballou

This paper identifies host-derived reactive nitrogen species as key drivers of the Cryptococcus neoformans yeast-to-titan switch by increasing endogenous superoxide, which promotes genotoxic stress and polyploidy, while requiring SOD activity for titan cell viability.

bioRxiv · Mar 1, 2021 · PreprintMicrobiology

The RAB32/BLOC-3 dependent pathway mediates host-defence against different pathogens in human macrophages

M. Baldassarre, V. Solano-Collado, A. Balci, R. Colamarino, I. M. Dambuza, D. M. Reid, H. M. Wilson, G. D. Brown, S. Mukhopadhyay, G. Dougan, S. Spano

This study identifies the Rab32/BLOC-3 pathway as a novel host-defense mechanism in macrophages that protects against bacterial and fungal pathogens.

bioRxiv · Jan 15, 2020 · PreprintMicrobiology

Host environmental conditions induce small fungal cell size and alter population heterogeneity in Cryptococcus neoformans

X. Zhou, H. Zafar, P. C. S. Sephton-Clark, S. H. Mohamed, A. Chapuis, M. Makarova, D. M. MacCallum, R. Drummond, I. M. Dambuza, E. R. Ballou

The paper investigates the relationship between titan cells, small cells, and titanides in Cryptococcus neoformans, showing their shared features and impact on aneuploidy and drug resistance.

bioRxiv · Jan 3, 2020 · PreprintMicrobiology

The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis

I. M. Dambuza, T. Drake, A. Chapuis, L. Taylor-Smith, N. LeGrave, T. Rasmussen, M. C. Fisher, T. Bicanic, T. S. Harrison, M. Jaspars, R. C. May, G. D. Brown, R. Yuecel, D. M. MacCallum, E. R. Ballou

This paper establishes an in vitro system to induce Titan cells in Cryptococcus neoformans, identifies bacterial peptidoglycan as an inducer, and shows that Titanisation is regulated and conserved across species.

bioRxiv · Sep 19, 2017Microbiology