Activated PI3Kδ specifically perturbs mouse Treg homeostasis and function leading to immune dysregulation
A. K. Singh, F. Al Qureshah, T. Drow, B. Hou, D. J. Rawlings
This study shows that increased PI3Kδ activity in Tregs disrupts their function and homeostasis, leading to immune dysregulation and autoimmunity in mice.
bioRxiv · Dec 21, 2023 · PreprintImmunology