Molecular species selectivity of lipid transport creates a mitochondrial sink for di-unsaturated phospholipids
M. F. Renne, X. Bao, M. W. Hokken, A. S. Bierhuizen, M. Hermansson, T. Ewing, X. Ma, R. C. Cox, J. F. Brouwers, C. H. De Smet, C. S. Ejsing, A. I. de Kroon
The paper investigates mitochondrial lipid import in yeast, showing that di-unsaturated phosphatidylserine is preferentially imported for conversion to phosphatidylethanolamine, with ERMES and Vps39p facilitating this process.
bioRxiv · Jun 8, 2020Biochemistry