X. Bao

Hyperbaric Oxygen-Induced acute lung injury: A Mouse Model Study on Pathogenesis and Recovery Dynamics

This study investigates hyperbaric oxygen-induced acute lung injury in mice, showing that vascular endothelial damage is most severe and slowest to recover, with inflammation peaking 12 hours post-exposure.

VHL loss enables immune checkpoint blockade therapy by boosting type I interferon response.

This study shows that VHL loss in ccRCC enhances anti-PD-1 therapy efficacy by increasing type I interferon response through HIF1/HIF2-mediated mtDNA leakage.

MAGIK: A rapid and efficient method to create lineage-specific reporters in human pluripotent stem cells

MAGIK improves knockin efficiency in hPSCs by using modRNAs to insert fluorescent proteins into lineage-specific genes without drug selection or single-cell cloning.

A proximity-dependent biotinylation map of cytosol-facing organelle outer membrane proteome in living Arabidopsis cells

The paper develops an OM proximity labeling system to map the proteome of cytosol-facing outer membranes in Arabidopsis cells and identifies potential receptors for protein translocation and organelle communication.

Bovine milk glycoproteins inhibit SARS-CoV-2 and influenza virus co-infection

This study shows that galactosylated glycoproteins from bovine milk inhibit both SARS-CoV-2 and influenza virus by blocking their interaction with ACE2.

Perturbation of mitochondrial Ca2+ homeostasis activates cross-compartmental proteostatic response in Arabidopsis

This study shows that disrupting mitochondrial Ca2+ homeostasis in Arabidopsis leads to misregulated gene expression and proteostatic responses, affecting plant growth and stress resistance.

Talaromyces marneffei suppresses human macrophages inflammatory by producing the truncated protein NCOR2-013 via TUT1-regulated alternative splicing

This study identifies TUT1-regulated alternative splicing of NCOR2 producing NCOR2-013 as a mechanism by which Talaromyces marneffei suppresses macrophage inflammation.

Robust genome editing via modRNA-based Cas9 or base editor in human pluripotent stem cells

This study develops modRNA-based CRISPR systems for efficient genome editing in human pluripotent stem cells, achieving higher knockout efficiency than plasmid-based methods.

Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy

This study engineers CAR-expressing neutrophils from human pluripotent stem cells, showing enhanced anti-tumor activity against glioblastoma in vitro and in vivo.

Changes of small non-coding RNAs by severe acute respiratory syndrome coronavirus 2 infection

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

A modified porous silicon microparticle promotes mucosal delivery of SARS-CoV-2 antigen and induction of potent and durable systemic and mucosal T helper 1 skewed protective immunity

Distribution and vulnerability of transcriptional outputs across the genome in Myc-amplified medulloblastoma cells

This study examines the distribution of transcriptional outputs in Myc-amplified medulloblastoma cells and identifies IMPDHs as a therapeutic target.

MLC Seq: De novo sequencing of full-length tRNA isoforms by mass ladder complementation

This paper introduces MLC-Seq, a method to sequence full-length tRNA isoforms and quantify RNA modifications, demonstrating its application on yeast and mouse tRNAs.

Direct induction of hemogenic endothelial progenitors from hPSCs by defined factors revealed by single-cell transcriptome analysis

This study identifies SOX17 as a key factor for generating hemogenic endothelial progenitors from hPSCs using single-cell transcriptomics and functional assays.

Acyl chain shortening induced by inhibition of acetyl-CoA carboxylase renders phosphatidylcholine redundant

This study shows that acyl chain shortening via ACC1 inhibition allows yeast to grow without phosphatidylcholine by altering lipid biosynthesis pathways.

Low-disturbance Farming Regenerates Healthy Deep Soil towards Sustainable Agriculture

This study shows that low-disturbance farming practices improve deep soil health, microbial diversity, and crop yield over ten years, supporting sustainable agriculture.

Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor

This study investigates the systemic inflammatory response in Dsg1-deficient mice and humans, revealing a psoriatic-like IL-17-skewed inflammation due to genetic Dsg1 loss.

TRPM2 promotes pancreatic cancer by PKC/MAPK pathway

This study investigates TRPM2's role in pancreatic cancer, finding it promotes proliferation, migration, and invasion through the PKC/MAPK pathway.

Global Profiling of the Lysine Crotonylome in Different Pluripotent States

This study profiles protein crotonylation in different mouse pluripotent states, identifying 3628 sites and showing that crotonyl-CoA promotes proteasome activity and delays differentiation.

Engineered Trimeric ACE2 Binds and Locks "Three-up" Spike Protein to Potently Inhibit SARS-CoVs and Mutants

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

Molecular species selectivity of lipid transport creates a mitochondrial sink for di-unsaturated phospholipids

The paper investigates mitochondrial lipid import in yeast, showing that di-unsaturated phosphatidylserine is preferentially imported for conversion to phosphatidylethanolamine, with ERMES and Vps39p facilitating this process.

Engineered illumination devices for optogenetic control of cellular signaling dynamics

The paper introduces LAVA devices for spatiotemporal optogenetic control of Wnt/β-catenin signaling in hESCs, showing dose-dependent activation and tissue patterning.

Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

Optogenetic control of Wnt signaling for modeling early embryogenic patterning with human pluripotent stem cells

This study uses optogenetic control of Wnt signaling to induce mesendoderm differentiation and gastrulation-like morphogenesis in human pluripotent stem cells.

Immune Landscape of Invasive Ductal Carcinoma Tumour Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature

The paper identifies an immune signature in invasive ductal carcinoma that predicts prognosis and response to immunotherapy.

GrgA as a potential target of selective antichlamydials

This study identifies GrgA as a potential target for selective antichlamydials by showing its necessity and sufficiency in BAH resistance.

Influence of food and Nosema ceranae infection on the gut microbiota of Apis cerana workers

This study examines how food type and Nosema ceranae infection affect the gut microbiota of Apis cerana workers, finding that beebread supports a more stable microbiota and reduces mortality from infection.

A role for GrgA in regulation of σ28-dependent transcription in the obligate intracellular bacterial pathogen Chlamydia trachomatis

This study shows GrgA activates both σ66 and σ28-dependent transcription in Chlamydia trachomatis by interacting with their non-conserved regions.

Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

The paper identifies how Mto1 docks at nuclear pore complexes via Crm1 and Nup146 to form non-centrosomal MTOCs.