Club cell TRPV4 as a damage sensor driving lung allergic inflammation
D. L. Wiesner, R. M. Merkhofer, C. L. Ober, G. C. Kujoth, J. E. Gern, R. Brockman Schneider, M. D. Evans, D. J. Jackson, T. F. Warner, N. Jarjour, S. J. Esnault, M. B. Feldman, M. J. Freeman, H. Mou, J. Vyas, B. S. Klein
The paper identifies TRPV4 in club cells as a sensor for junction damage that drives lung allergic inflammation through calcium and calcineurin signaling.
Cell Host & Microbe · Apr 1, 2020Peer-reviewedImmunology