A non-canonical role for glutamate decarboxylase 1 in cancer cell amino acid homeostasis, independent of the GABA shunt.
B. Samborska, T. Griss, E. H. Ma, N. Jones, K. S. Williams, A. Sergushichev, R. M. Johnson, E. Esaulova, E. Loginicheva, B. Flynn, J. Blagih, M. N. Artyomov, R. G. Jones, E. E. Vincent
This study identifies a non-canonical role for GAD1 in cancer cell amino acid homeostasis, independent of the GABA shunt, by regulating amino acid transporter expression.
bioRxiv · Feb 17, 2021 · PreprintCancer Biology