High-throughput single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenic Staphylococcus aureus communities.
J. Hira, B. Singh, T. Halder, A. Mahmutovic, C. Ajayi, A. A. Sekh, K. Hegstad, M. Johannessen, C. S. Lentz
The paper introduces CPPT, a method to profile and trace phenotypic subpopulations in isogenic bacterial communities, revealing clinically relevant biomarkers for antibiotic resistance.
bioRxiv · Nov 2, 2023 · PreprintMicrobiology