B. Singh

MELD-Adapt: On-the-Fly Belief Updating in Integrative Molecular Dynamics

MELD-Adapt dynamically evaluates data reliability to improve structure prediction accuracy by adjusting initial beliefs and identifying reliable data fractions.

Human Breast Milk EVs Mitigate Endothelial Dysfunction: Preliminary Study

This study investigates the therapeutic potential of human breast milk EVs in mitigating endothelial dysfunction, showing reduced inflammation and improved vascular function in vitro and in mice.

Histones are exosome membrane proteins regulated by cell stress

This study identifies histones as exosome membrane proteins regulated by cell stress, showing they are secreted via the exosome pathway and lack nuclear post-translational modifications.

Sifting Through the Noise: A Computational Pipeline for Accurate Prioritization of Protein- Protein Binding Candidates in High-Throughput Protein Libraries

This paper introduces a computational pipeline using AlphaFold2 to prioritize protein-protein binding candidates from high-throughput libraries and identify binding epitopes.

Epsins oversee smooth muscle cell reprogramming by influencing master regulators KLF4 and OCT4.

This study shows Epsins regulate smooth muscle cell reprogramming by modulating OCT4 and KLF4, with implications for coronary artery disease.

Nitrogen Management on Improving Resilience of Flood-Tolerant (Sub1) Rice Varieties in Flood-Prone Rainfed Lowlands

This study investigates the effect of nitrogen management on the survival and productivity of flood-tolerant rice varieties, finding that a specific nitrogen application strategy improves submergence tolerance and yield.

Targeting endothelial FOXO1 protects diabetic β-cells and improves wound healing

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

High-throughput single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenic Staphylococcus aureus communities.

The paper introduces CPPT, a method to profile and trace phenotypic subpopulations in isogenic bacterial communities, revealing clinically relevant biomarkers for antibiotic resistance.

Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

This study inhibits the IST1-CHMP1B interaction in ESCRT-III, impairing endosomal recycling and inducing unconventional LC3 lipidation at stalled endosomes.

Locus specific human endogenous retroviruses reveal new lymphoma subtypes

The paper identifies unique HERV signatures in B-cell lymphoma subtypes that can improve classification and diagnosis when combined with gene expression.

Evolving spike-protein N-glycosylation in SARS-CoV-2 variants

This study compares N-glycan processing in SARS-CoV-2 spike-proteins across variants to understand immune evasion mechanisms.

Isolation of Actinomyces cricetomyis sp. nov from orocervicofacial abscesses of African giant pouched rats (Cricetomys ansorgei)

The paper isolates and characterizes a novel Actinomyces species from abscesses in African giant pouched rats.

Host selection has stronger impact on leaf microbiome assembly compared to land-management practices

This study shows host selection has a stronger impact on leaf microbiome assembly than land-management practices in Eucalyptus saligna plantations.

SiHDA9 interacts with SiHAT3.1 and SiHDA19 to repress dehydration responses through H3K9 deacetylation in foxtail millet

The paper identifies SiHDA9's role in repressing drought responses by deacetylating H3K9 on target genes in foxtail millet through interaction with SiHAT3.1 and SiHDA19.

Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology

This study uses transgenic mouse models to show that a heightened type 1 IFN response protects against SARS-CoV-2-induced immunopathology, with Irgm1 as a potential therapeutic target.

Transcriptome and biochemical analysis pinpoint multi-layered molecular processes associated with iron deficiency tolerance in hexaploid wheat

This study identifies molecular and biochemical mechanisms underlying Fe deficiency tolerance in hexaploid wheat by comparing tolerant and susceptible cultivars.

Convergence of two global regulators to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis

The paper identifies a regulatory mechanism where CRP and PhoP co-activate virulence genes in M. tuberculosis through protein-protein interactions and promoter recruitment.

Response of the plant core microbiome to Fusarium oxysporum infection and identification of the pathobiome.

This study identifies how the core microbiome and pathobiome of cotton plants respond to Fusarium oxysporum infection and shows that certain microbial members can protect against disease.

Isolation and Characterization of SARS-CoV-2 strains circulating in Eastern India.

The paper isolates and characterizes five SARS-CoV-2 strains from India, showing variations in cytotoxicity and cell line permissiveness, and finds both Covaxin and Covishield vaccines neutralize all isolates effectively.

A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells.

Vegetation structure determines cyanobacterial communities during soil development across global biomes

The paper investigates how vegetation structure influences soil cyanobacterial communities across soil development in global biomes, finding stable communities in most cases but shifts during vegetation transitions.

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

This paper shows that FA pathway deficiency in squamous cell carcinomas leads to high structural variant rates and copy number alterations, linking genomic instability to tumor progression.

Evaluation of the sensitivity and specificity of three diagnostic tests for Coxiella burnetii infection in cattle and buffaloes in Punjab (India) using Bayesian latent class analysis

Gut microbial diversity in stingless bees is linked to host wing size and is influenced by geography

This study analyzes the gut microbiomes of two stingless bee species, finding that bacterial richness in T. carbonaria correlates with host wing size and geography.

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

This study uses longitudinal single-cell RNA sequencing in rhesus macaques to show that myeloid cell interferon responses correlate with SARS-CoV-2 clearance.

Measles virus exits human airway epithelia via infectious center sloughing

This paper identifies a novel mechanism by which measles virus exits human airway epithelia through sloughing of infectious centers, enhancing its transmissibility.

Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host-factors having implication in the disease pathogenesis and severity

This study uses quantitative proteomics to analyze SARS-CoV-2-infected hamster lung tissues, identifying differentially expressed proteins and pathways linked to disease pathogenesis and severity.

Primary saturation of α,β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity

This study investigates the electrophilicity of saturated oxo-fatty acids and finds that mono-saturation retains electrophilicity, while double saturation abolishes it, implicating PTGR1 in their metabolism.

Phylogeography and population genetic structure of red muntjacs: Evidence of enigmatic Himalayan red muntjac from India

This study identifies a new mitochondrial lineage of red muntjac in Northwest India, revealing three genetic clusters and suggesting conservation actions for the Himalayan red muntjac.

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

This study identifies transcriptional signatures of IFN signaling and neutrophil degranulation in SARS-CoV-2 infected rhesus macaques and humans, highlighting age-related differences and shared pathways with tuberculosis.