Biomolecular Condensation Drives Leukemia Caused by NUP98-Fusion Proteins
S. Terlecki-Zaniewicz, T. Eder, J. Schmoellerl, T. Humer, N. Kuchynka, K. Parapatics, E. Heyes, F. G. Liberante, A. C. Müller, F. Grebien
This study identifies biomolecular condensation as a mechanism by which NUP98-fusion proteins drive leukemia by altering condensate composition and gene regulation.
bioRxiv · Nov 16, 2020 · PreprintCancer Biology